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Editorial Board
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Phosphate homeostasis in the yeast Saccharomyces cerevisiae, the key role of the SPX domain-containing proteins
27 January 2012
Abstract: In the yeast Saccharomyces cerevisiae, a working model for nutrient homeostasis in eukaryotes, inorganic phosphate (Pi) homeostasis is regulated by the PHO pathway, a set of phosphate starva...
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David Secco,
Chuang Wang,
Huixia Shou,
James Whelan
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289-295
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| Hypothesis |
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Phosphosite conservation in single domain orthologs versus paralogs: A way to combine differential regulation with redundant core functions
18 January 2012
Highlights: ► Isoform co-expression in various tissues necessitates differential regulation. ► Conserved point mutations in single domain paralogs with similar core functions. ► Data mining indicates ...
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Lynn Huyck,
Marleen Van Troys,
Christophe Ampe
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296-302
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| Research Letters with SDA |
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Hypoxia-induced SM22α in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo- and radiation therapy
11 January 2012
Highlights: ► SM22α is induced in A549 non-small cell lung carcinoma cells by hypoxia. ► SM22α overexpression increased chemo- and radiation-resistance of A549 NSCLC cells. ► Hypoxia-mediated inductio...
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Tae Rim Kim,
Eun Wie Cho,
Sang Gi Paik,
In Gyu Kim
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303-309
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Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: Increased therapeutic dosage and immunogenicity
16 January 2012
Highlights: ► Synaptotagmin-II of rat and mouse acts as neuronal high affinity receptor for BoNT/B and G. ► Mutation F54L converts rat synaptotagmin-II to a low affinity receptor of BoNT/B and G. ► F5...
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Jasmin Strotmeier,
Gesche Willjes,
Thomas Binz,
Andreas Rummel
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310-313
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Crystal structures of the coil 2B fragment and the globular tail domain of human lamin B1
16 January 2012
Highlights: ► Crystal structures of the human lamin B1 coil 2B and tail domains are presented. ► These two domains in lamin B1 adopt conserved folds to those of lamin A/C. ► An intermolecular disulfid...
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Jianbin Ruan,
Chao Xu,
Chuanbing Bian,
Robert Lam,
Jia-Pey Wang,
Joanna Kania,
Jinrong Min,
Jianye Zang
et al.
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314-318
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Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4
18 January 2012
Highlights: ► This is the first report to clarify how FRP acts in immunity on a molecular level. ► FRP associates with CD14 on the cell surface and triggers TLR4 signaling. ► FRP is considered to be a...
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Kosaku Murakami,
Masao Tanaka,
Takashi Usui,
Daisuke Kawabata,
Aoi Shiomi,
Mikiko Iguchi-Hashimoto,
Masakazu Shimizu,
Naoichiro Yukawa,
Hajime Yoshifuji,
Takaki Nojima,
Koichiro Ohmura,
Takao Fujii,
Hisanori Umehara,
Tsuneyo Mimori
et al.
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319-324
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Novel assay with fluorescence-labelled PrP peptides for differentiating L-type atypical and classical BSEs, and scrapie
27 January 2012
Highlights: ► Fluorescence-labelled peptides were used for detecting PrPSc. ► Five PrP peptides changed fluorescence intensities with prion-affected animal samples. ► Reactivity was different among at...
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Kazuo Kasai,
Akiyoshi Hirata,
Takafumi Ohyama,
Kiyoshi Nokihara,
Takashi Yokoyama,
Shirou Mohri
et al.
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325-329
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Cataract-linked γD-crystallin mutants have weak affinity to lens chaperones α-crystallins
27 January 2012
Highlights: ► How can destabilizing mutations of lens γ-crystallin cause cataract? ► Cataract-causing mutations stabilize an unfolding intermediate of γD-crystallin. ► Cataract-causing mutants of γD-c...
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Sanjay Mishra,
Richard A. Stein,
Hassane S. Mchaourab
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330-336
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Unusual NADPH conformation in the crystal structure of a cinnamyl alcohol dehydrogenase from Helicobacter pylori in complex with NADP(H) and substrate docking analysis
23 January 2012
Highlights: ► The binary structure of HpCAD complex NADP(H) is solved at 2.18Å. ► An unusual conformation of the 2′phosphate group of the NADPH, not seen in other CAD structures, was found. ► Docking ...
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Kyung Hye Seo,
Ningning Zhuang,
Cong Chen,
Jae-Young Song,
Hyung-Lyun Kang,
Kwang-Ho Rhee,
Kon Ho Lee
et al.
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337-343
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Dimerization, but not phosphothreonine binding, is conserved between the forkhead-associated domains of Drosophila MU2 and human MDC1
23 January 2012
Highlights: ► The crystal structure of the MU2 FHA domain reveals a dimer. ► The FHA dimer interface is different between MU2 and MDC1. ► The phosphothreonine-binding pocket of MU2 FHA is degenerate. ...
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Shukun Luo,
Keqiong Ye
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344-349
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Crystal structure of cce_0566 from Cyanothece 51142, a protein associated with nitrogen fixation in the DUF269 family
27 January 2012
Highlights: ► First structural characterization of a protein from the DUF269 family. ► Dali search indicates protein fold is unique in current protein space. ► Homodimer with each unit containing 8 α-...
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Garry W. Buchko,
Howard Robinson
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350-355
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| Research Letters |
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Yeast ribosomal protein S3 possesses a β-lyase activity on damaged DNA
11 January 2012
Highlights: ► Yeast Rps3p cleaves not only AP sites and pyrimidine dimers but also 8-oxo-G. ► Yeast Rps3p could cleave pyrimidine dimers without glycosylase activity. ► Asp154 and Lys200 are identifie...
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Ki Moon Seong,
Sang-Oun Jung,
Hag Dong Kim,
Hee Ju Kim,
You-Jin Jung,
Soo-Young Choi,
Joon Kim
et al.
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356-361
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Identification of essential sequences for cellular localization in the muscle-specific ubiquitin E3 ligase MAFbx/Atrogin 1
12 January 2012
Highlights: ► Sequences governing nucleo-cytoplasmic shuttling of MAFbx in muscle atrophy. ► A non-canonical nuclear export signal controls cytoplasmic localization of MAFbx. ► Increasing informations...
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Lagirand-Cantaloube Julie,
Batonnet-Pichon Sabrina,
Leibovitch Marie-Pierre,
Serge A. Leibovitch
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362-367
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Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFα enhances GPR84 expression in adipocytes
11 January 2012
Highlights: ► GPR84 has been identified as a receptor for medium-chain fatty acids (MCFAs). ► GPR84 appears in white adipose tissue during the onset of obesity. ► TNFα from macrophages enhances GPR84 ...
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Hiroshi Nagasaki,
Takaaki Kondo,
Masahiro Fuchigami,
Hiroyuki Hashimoto,
Yoshihisa Sugimura,
Nobuaki Ozaki,
Hiroshi Arima,
Akira Ota,
Yutaka Oiso,
Yoji Hamada
et al.
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368-372
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Identification and characterization of an LCAT-like Arabidopsis thaliana gene encoding a novel phospholipase A
11 January 2012
Abstract: A previously uncharacterized Arabidopsis lecithin:cholesterol acyltransferase (LCAT) family gene (At4g19860) was functionally expressed in yeast, where it was demonstrated to encode a novel ...
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Guanqun Chen,
Michael S. Greer,
Ida Lager,
Jenny Lindberg Yilmaz,
Elzbieta Mietkiewska,
Anders S. Carlsson,
Sten Stymne,
Randall J. Weselake
et al.
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373-377
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Sorbitol dehydrogenase of Aspergillus niger, SdhA, is part of the oxido-reductive d-galactose pathway and essential for d-sorbitol catabolism
11 January 2012
Highlights: ► We identified the sorbitol dehydrogenase gene in Aspergillusniger. ► It is part of the oxido-reductive d-galactose pathway. ► It is upregulated on d-sorbitol, d-galactose and galactitol....
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Outi M. Koivistoinen,
Peter Richard,
Merja Penttilä,
Laura Ruohonen,
Dominik Mojzita
et al.
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378-383
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PEDV ORF3 encodes an ion channel protein and regulates virus production
12 January 2012
Highlights: ► Computational modeling of PEDV OFR3 protein. ► Wild-type PEDV ORF3 protein functions as an ion channel and regulates virus production. ► The truncated protein encoded by an attenuated-ty...
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Kai Wang,
Wei Lu,
Jianfei Chen,
Shiqi Xie,
Hongyan Shi,
Haojen Hsu,
Wenjing Yu,
Ke Xu,
Chao Bian,
Wolfgang B. Fischer,
Wolfgang Schwarz,
Li Feng,
Bing Sun
et al.
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384-391
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MicroRNA-195-5p suppresses glucose uptake and proliferation of human bladder cancer T24 cells by regulating GLUT3 expression
16 January 2012
Highlights: ► miR-195-5p negatively regulates the expression of GLUT3 through GLUT3 3’UTR. ► miR-195-5p is the first identified microRNA that targets GLUT3. ► Over-expression of miR-195-5p decreases G...
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Xiang Fei,
Manlong Qi,
Bin Wu,
Yongsheng Song,
Yueping Wang,
Tingting Li
et al.
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392-397
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MIZ1, an essential protein for root hydrotropism, is associated with the cytoplasmic face of the endoplasmic reticulum membrane in Arabidopsis root cells
25 January 2012
Highlights: ► MIZ1 is a previously uncharacterized protein encoded by a gene essential for root hydrotropism. ► GFP-tagged MIZ1 is associated with the endoplasmic reticulum membrane (ER) at the cytoso...
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Tomokazu Yamazaki,
Yutaka Miyazawa,
Akie Kobayashi,
Teppei Moriwaki,
Nobuharu Fujii,
Hideyuki Takahashi
et al.
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398-402
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SNPs of hemocyanin C-terminal fragment in shrimp Litopenaeus vannamei
12 January 2012
Highlights: ► We found for the first time that the C-terminus of hemocyanin possessed SNPs. ► It could be modulated by a specific environmental stress. ► Some specific SNP sites might be associated wi...
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Xianliang Zhao,
Lingling Guo,
Yueling Zhang,
Yao Liu,
Xiaoyu Zhang,
Jingsheng Lun,
Jiehui Chen,
Yuanyou Li
et al.
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403-410
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Verification of the interdomain contact site in the inactive monomer, and the domain-swapped fold in the active dimer of Hsp33 in solution
18 January 2012
Highlights: ► We examine physiological relevance of the known crystal structures of Hsp33. ► Interdomain contact site in the inactive monomer is validated in solution. ► Domain-swapped fold of the act...
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Yoo-Sup Lee,
Kyoung-Seok Ryu,
Seo-Jin Kim,
Hyun-Suk Ko,
Dae-Won Sim,
Young Ho Jeon,
Eun-Hee Kim,
Wahn-Soo Choi,
Hyung-Sik Won
et al.
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411-415
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Single-particle tracking of immunoglobulin E receptors (FcεRI) in micron-sized clusters and receptor patches
18 January 2012
Highlights: ► Super-resolution single-particle tracking of immune receptors. ► FcεRI receptors maintain lateral mobility inside receptor clusters. ► FcεRI receptor immobilization is not required for s...
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Kathrin Spendier,
Keith A. Lidke,
Diane S. Lidke,
James L. Thomas
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416-421
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MiR-18a regulates expression of the pancreatic transcription factor Ptf1a in pancreatic progenitor and acinar cells
18 January 2012
Highlights: ► We explore the role of miR-18a in pancreatic progenitor and acinar cells. ► We find that miR-18a targets Ptf1a 3′UTR to decrease its protein and mRNA levels. ► MiR-18a regulates pancreat...
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Yankun Yang,
Lei Ding,
Yang An,
Zhen-wu Zhang,
Yanhe Lang,
Sheng Tai,
Fangqi Guo,
Chun-Bo Teng
et al.
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422-427
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Mitochondrial ATP-sensitive potassium channel activity and hypoxic preconditioning are independent of an inwardly rectifying potassium channel subunit in Caenorhabditis elegans
23 January 2012
Highlights: ► A mitochondrial KATP channel (mKATP) is central to ischemic preconditioning (IPC). ► A Kir family member is thought to form the mKATP. ► C. elegans benefit from IPC and display mKATP act...
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Andrew P. Wojtovich,
Peter DiStefano,
Teresa Sherman,
Paul S. Brookes,
Keith Nehrke
et al.
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428-434
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RUVBL2 is a novel repressor of ARF transcription
27 January 2012
Highlights: ► RUVBL2 transcriptionally represses ARF expression. ► RUVBL2 binds to the distal region of ARF promoter. ► RUVBL2 down-regulates p53 in an ARF-dependent manner.Abstract: ARF is the second...
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Chongwei Xie,
Wenyu Wang,
Fan Yang,
Mian Wu,
Yide Mei
et al.
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435-441
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Cyclin-dependent kinase 4 is a novel target in micoRNA-195-mediated cell cycle arrest in bladder cancer cells
27 January 2012
Highlights: ► miR-195 is down-regulated in bladder cancer tissue samples. ► miR-195 inhibits bladder cancer cell T24 growth both in vitro and in vivo. ► miR-195 could induce T24 cell cycle arrest by s...
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Yiwei Lin,
Jian Wu,
Hong Chen,
Yeqing Mao,
Yunfu Liu,
Qiqi Mao,
Kai Yang,
Xiangyi Zheng,
Liping Xie
et al.
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442-447
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Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism
27 January 2012
Highlights: ► We revealed that Bach1 has a novel function beyond transcriptional regulation. ► Bach1 functions to maintain mitotic chromosome alignment. ► The exclusion of Bach1 from mitotic chromosom...
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Jie Li,
Takuma Shiraki,
Kazuhiko Igarashi
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448-454
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Saccharomyces cerevisiae gene YMR291W/TDA1 mediates the in vivo phosphorylation of hexokinase isoenzyme 2 at serine-15
27 January 2012
Highlights: ► The monomer–homodimer equilibrium of Hxk2 is affected by serine-15 phosphorylation. ► High resolution clear native PAGE is appropriate for phosphohexokinase detection. ► Protein kinase “...
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Karina Kettner,
Udo Krause,
Sophie Mosler,
Claudia Bodenstein,
Thomas M. Kriegel,
Gerhard Rödel
et al.
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455-458
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Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles
27 January 2012
Highlights: ► Bordetella pertussis produce outer membrane vesicles (OMV) that contain biologically active adenylate cyclase toxin (ACT). ► OMV–ACT enter host cells by a mechanism distinct from soluble...
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Gina M. Donato,
Cynthia S. Goldsmith,
Christopher D. Paddock,
Joshua C. Eby,
Mary C. Gray,
Erik L. Hewlett
et al.
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459-465
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The β1 domain of protein G can replace the chorismate mutase domain of the T-protein
27 January 2012
Highlights: ► Gβ1 can replace AroQT in the T-protein. ► AroQT/TyrA specific-contact interface is not important to maintain a functional T-protein. ► Gβ1N-terminal β-hairpin residues are important to m...
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Joel Osuna,
Humberto Flores,
Gloria Saab-Rincón
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466-471
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